Like the first generation of cars in the 20th century, autonomous vehicles will have a powerful effect on the way cities are shaped, operated, and experienced in the coming decades. AVs will change not just transportation, but also land use, health, education, work, sustainability, and local finance. How can city leaders maximize the benefits and minimize the challenges of this technology? How can cities learn from the mistakes of the past and use AVs to improve the lives of all residents? This panel at South by Southwest 2018 featured Brian Kenner, Deputy Mayor for Planning and Economic Development, Washington, DC, Karina Ricks, Director, Department of Mobility and Infrastructure, Pittsburgh, PA, and Rob Spillar, Director, Department of Transportation, Austin, TX, and was moderated by Jennifer Bradley, Director, Center for Urban Innovation, The Aspen Institute.