In June 2018, the Aspen Health Strategy Group met for three days and took on hard questions and explored the challenges associated with reducing the burden of chronic disease on our nation. We are pleased to present the final report from our work, based upon the group’s rich discussion. In the tradition of the thought-provoking conversations and dialogue on how to address critical societal issues — the hallmark of the Aspen Institute — the report includes five big ideas to prevent chronic disease.